Osteoconductive carriers for integrated bone repair

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Osteoconductive carriers for integrated bone repair

Successful bone repair is judged in achieving restitution of space and mechanical integrity, and in regaining function. When the biology or anatomy are insufficient to attain a full repair, therapeutic use of graft material has been used to omit compliance features such as strain tolerance, reduced stiffness, and attenuated strength, and instead promote primary or membranous-type bone formation...

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• Repair of Critical Femoral Defects in Rats by an Osteoconductive Synthetic Bone Graft

Filion, T; Li, X; Kreider, JM; Goldstein, SA; Ayers, DC; +Song, J University of Massachusetts Medical School, Worcester, MA; University of Michigan, Ann Arbor, MI +Senior author [email protected]; Filion and Li contributed equally INTRODUCTION: There is a pressing need for the development of more effective strategies to repair critical-sized bony defects in patients who have had volumetric ...

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Effect of osteoconductive hyaluronate hydrogels on calvarial bone regeneration

BACKGROUND Without exploitation of possibly immunogenic and carcinogenic bone morphogenetic protein, we developed simple but clinically feasible artificial bone graft using osteoconductive hyaluronate (HA) hydrogels and bioactive MegaGen synthetic bone (MGSB). METHODS HA hydrogels were synthesized by the crosslinking reaction between carboxyl groups of HA and amine groups of gelatin (GEL). Th...

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The role of the osteoconductive scaffold in synthetic bone graft.

Autogenous bone is regarded as the gold standard for bone graft materials as it provides 3 elements necessary to generate and maintain bone: scaffolding for osteoconduction, growth factors for osteoinduction, and progenitor cells for osteogenesis. Allograft is more limited than autograft in these essential elements and yields more variable clinical results. Composite synthetic grafts offer an a...

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Novel Resorbable and Osteoconductive Calcium Silicophosphate Scaffold Induced Bone Formation

This aim of this research was to develop a novel ceramic scaffold to evaluate the response of bone after ceramic implantation in New Zealand (NZ) rabbits. Ceramics were prepared by the polymer replication method and inserted into NZ rabbits. Macroporous scaffolds with interconnected round-shaped pores (0.5-1.5 mm = were prepared). The scaffold acted as a physical support where cells with osteob...

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ژورنال

عنوان ژورنال: SAS Journal

سال: 2009

ISSN: 1935-9810

DOI: 10.1016/j.esas.2009.09.006